The Samuel lab brings a positive and creative force to problem solving. We tackle challenges by collaborating to develop new approaches to compelling questions. These include new technologies to see beyond the diffraction limit of light and to molecularly query single neurons and synapses.
We are developing new approaches to visualize neural development and resiliency in vivo, resulting in some of the first high-resolution views into this process. These methods rely on 3D high-resolution stochastic optical reconstruction microscopy (STORM) and exchange points accumulation for imaging in nanoscale topography (PAINT) to achieve 3D reconstruction with 20-50nm resolution (i.e., beyond the diffraction). These methods can be multiplexed to enable simultaneous imaging of whole neurons, their synapses, and numerous molecules within neurons and their neighbors.